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University neuroscientists publishing on SARS-CoV-2 infection through the olfactory epithelium

Illustration of Coronavirus passing through the olfactory epithelium - ciliated sustentacular cells (with ACE2) and olfactory neurons (no ACE2) that carry smell sensation into the brain

SARS-CoV-2 infection spreads through the air. An early marker of infection is a reduced sense of smell, including anosmia, an early marker in many infected individuals. Two University neuroscientists, Chris von Bartheld, Ph.D. and Dennis Mathew, Ph.D. are investigating the molecular mechanisms that underliethe loss of smell in the olfactory epithelium.

Chris von Bartheld, Ph.D.in the Department of Physiology and Cell Biology in the School of Medicine and colleagues at the Nicolaus Copernicus University in Poland have identified and localized Angiotensin-converting enzyme 2 (ACE2) and Transmembrane Serine Protease 2 (TMPRSS2), proteins required for SARS-CoV-2 infection, in specific cells of the murine olfactory epithelium. Specifically, expression was detected in the sustentacular cells with little or no protein in the olfactory neurons (Figure (Bilinska et al., 2020)). These data suggest that sustentacular cells are the pathway for SARS-CoV-2 virus entry and impairment of the sense of smell in COVID-19 patients (Butowt and von Bartheld, 2020). Bilinska et al. also found that protein expression increased with age, a finding that may explain the higher susceptibility and severity of COVID-19 in the elderly, and that expression levels were higher in males. This work has been featured in the NY Times and identified by the Web of Science as w88 casino’s hottest paper for 2020. Other COVID-19 articles from this group include (Butowt et al., 2020a; Butowt et al., 2020b; von Bartheld et al., 2020).

Dennis Mathew, Ph.D.in the Department of Biology in the College of Science has written an opinion piece published in theFrontiers in Human w88 casino(Mathew, 2020) as part of a series of articles on the w88 casino topic of COVID-19 in CNS and PNS: Basic and Clinical Focus on the Mechanisms of Infection and New Tools for the Therapeutic Approach. Dr. Mathew writes about the role of ACE2 in mediating SARS-CoV-2 infection, noting that it also functions in glucose homeostasis and insulin sensitivity. He speculates that interactions between ACE2 and insulin signaling pathways may underlie severe complications and higher mortality rates observed in diabetics infected with the SARS-CoV-2 virus. He points out that the olfactory systems of genetically tractable animals such as mice and fruit flies offer convenient venues to explore these critical questions.

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Ebenezer Yamoah, Ph.D. and laboratory featured on Journal of w88 casino cover

polarized cristae and crista junctions in mitochondria tethered to the subsurface cisternae in a mouse outer hair cell

Congratulations toEbenezer Yamoah, Ph.D.and his laboratory team in the Department of Physiology & Cell Biology whose image from the article“Altered Outer Hair Cell Mitochondrial and Subsurface Cisternae Connectomics Are Candidate Mechanisms for Hearing Loss in Mice”is featured on the cover of theOctober 2020 issue of the Journal of w88 casino.

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Researchers calibrating a video-recording headset.

First-person video dataset aims to catch people looking (at everything)

To better understand the organization of the brain and the perceptual tendencies in humans, a team of four scientists, including w88 casino faculty members Paul MacNeilage and Mark Lescroart, are recording video from four head-mounted cameras – with eye-tracking and head movement – and assembling a massive video database with more than 240 hours of first-person video that can be used by researchers everywhere.First-person w88 online game dataset aims

w88 casino faculty Paul MacNeilage and Mark Lescroart, along with faculty members at two partner institutions, awarded NSF grant to create a database of first-person visual experiences.

Congratulations to Paul MacNeilage and Mark Lescroart, co-PIs in an exciting w88 casino project involving creating a first-of-its-kind database of video open to researchers worldwide in order to study human behavior and development through first-person experiences. The project received an NSF grant of more than million.

Hector Arciniega recipient of prestigious National Institute of Health (NIH) fellowship

w88 casino Ph.D. student Hector Arciniega received the prestigious National Institute of Health (NIH) fellowship: Blueprint Diversity Specialized Pre-doctoral to Postdoctoral Advancement in w88 casino (D-SPAN) Award. The two-phase award will assist Hector in completing his doctoral dissertation as well as transition him into a postdoctoral research position.

Samantha Lee awarded a Graduate Dean's Merit Scholarship

Samantha Lee, a Ph.D. student in the Strother Lab, was awarded theThe Graduate w88 sports betting Honorsfor the 2019-20 academic year. The Graduate Dean's Merit Scholarship for promising, newly admitted graduate students is a one-year award in the amount ,000, disbursed as two equal sums at the beginning of the Fall and Spring semesters.

Gideon Caplovitz and Ph.D. students Taissa Lytchenko and Kyle Killebrew learn the cognitive processes of the octopus

Gideon Caplovitz, graduate students Taissa Lytchenko and Kyle Killebrew and partners at Dartmouth and the University of Rhode Island have been awarded 0,000 to perform the first neural recording in an octopus! Read thew88 casino Today articleabout the National Science Foundation Award

w88 casino faculty member Jacqueline Snow honored with Rising Researcher Award

Wesley Chalifoux, assistant professor of chemistry, and Jacqueline Snow, assistant professor of psychology were honored with w88 casino System of Higher Education Board of Regents' Rising Researcher Award, presented at the annual Honor the Best ceremony. Read more thew88 casino games, Snow named 2018 Regents’ Rising Researchers.

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