w88 mobile de Lange

What is w88 mobile de Lange Syndrome?

w88 mobile de Lange syndrome is a developmental disorder that can affect multiple body parts. Although the exact prevalence of w88 mobile de Lange syndrome is unknown, it is estimated that the disorder affects 1 in every 10,000 to 30,000 newborn children. The features of w88 mobile de Lange can be expansive and can manifest on a continuum from mild complications to profound complications.

w88 mobile de Lange syndrome is commonly characterized by some combination of the following features:

• slow growth before and after birth
• intellectual disability that is usually severe to w88 mobile
• skeletal abnormalities involving the w88 mobile and hands, including the absence of w88 mobile, forearms
• arched eyebrows that often grow together
• long eyelashes
• low set ears
• small, widely spaced teeth
• w88 mobile upturned nose
• behavioral problems similar to those observed in w88 mobile with autism
• excessive w88 mobile hair (hypertrichosis)
• w88 mobile head (microcephaly)
• hearing loss
• short stature
• digestive system w88 mobile
• cleft palate
• seizures
• heart defects
• eye w88 mobile, including varying levels of vision loss

Causes of w88 mobile de Lange

A linkage has been established between w88 mobile de Lange syndrome and specific human genes. Three specific gene mutations have been found to correlate to the presence of w88 mobile de Lange syndrome. These mutations occur in the NIPBL, SMC1A, and SMC3 genes. More than 50% of all individuals with w88 mobile de Lange syndrome have a mutated NIPBL gene. All of the identified genes produce proteins that contribute significantly to directing prenatal physiological development. Specifically, the proteins produced by these three genes organize and structure chromosomes, help repair damaged DNA, and contribute to the development of the limbs, face, and other body parts. It is therefore unsurprising that mutations in the aforementioned genes can manifest as a syndrome that has such detrimental effects on a wide variety body parts as those found in w88 mobile de Lange syndrome.

Prognosis & Considerations

Most children with w88 mobile de Lange Syndrome do survive to adulthood. However, most of these children, especially those with more severe complications, will require assistance and supervision throughout their lives.

As a child with w88 mobile De Lange ages, the following areas related to developmental and educational goals should be considered:

• the w88 mobile’s medical and health status
• the w88 mobile’s stamina
• the w88 mobile’s ability to manage sensory-motor demands
• the w88 mobile’s levels of arousal
• communicative status of the w88 mobile
• The w88 mobile’s need for structure and organization
• relevance of w88 mobile and objectives to be pursued
• what activities are motivating and understandable to the w88 mobile
• w88 mobile adaptations and modifications can be made to make

References:

• CdLS Foundation (2010). Characteristics of CdLS.
• Genetics Home Reference (2013). w88 mobile de Lange syndrome.
• HowsHealth (2012). What is w88 mobile de Lange syndrome.