Summary

Professional Biography

• 1971 - present:Assistant Professor, Associate Professor and Full Professor at the w88 online game Nevada, Reno
• 1996 - 2005:Mycology Editor for Infection and Immunity
• 1996 - 2005: NIH MERIT awardee
• 2014:Recipient, Rhoda Benham Award
• 2012:Outstanding Researcher, w88 online game Nevada, Reno
• 2000:Visiting scientist, Oxford w88 online game, Oxford, England
• 1980: Sabbatical, The Rockefeller w88 online game, New York City
• Published over 140 peer-reviewed publications
• Served on over 35 NIH study sections and advisory panels

w88 online game Interests

Dr. Kozel’s w88 online game focuses on development of rapid, inexpensive, point-of-care diagnostics for infectious disease with an emphasis on fungal infections. Improved tests can facilitate early diagnosis of infection and early administration of appropriate antimicrobial therapy. Early treatment will save lives and limit development of antibiotic resistance that follows overuse and inappropriate use of antimicrobial agents.

Diagnostics under development in the Kozel laboratory aim to detect microbial antigens that are shed into body fluids during infection. The means for detection is the immunoassay. The assay platform is the lateral flow immunoassay (LFA), the same platform that is used in the home pregnancy test or the COVID-19 antigen test. LFA is rapid (minutes to result), inexpensive, and can be performed by personnel with minimal training. As a consequence, these assays are ideally suited for use in resource-limited settings.

Previous studies led to the development of monoclonal antibodies that were used to construct an LFA for early diagnosis of cryptococcal meningitis. There are 250,000 cases of cryptococcal meningitis each year, resulting in 180,000 deaths. The Centers for Disease Control has estimated that the LFA for diagnosis of cryptococcal meningitis will save as many as 50-100,000 lives each year, particularly in sub-Saharan Africa.

Current studies aim to develop diagnostics for i) invasive fungal disease in the immunocompromised patient, ii) “black mold” infections in COVID patients, iii) fungal nail infections, and iv) coccidioidomycosis (Valley Fever).

Current Lab Members

• Amanda Burnham-Marusich w88 online gameD., Faculty Researcher
• Lawrence Mariano,w88 online game III
• Kathleen Zayac, w88 online game II
• Marcie Hollingsworth, w88 online game IV
• Peter Thorkildson, w88 online game IV

Past Lab Members

• Frank Swenson M.S.
• Terrence McGaw M.S.
• Thomas F. Eckert M.S.
• Annette Schlageter w88 online gameD.
• Elmer Otteson w88 online gameD.
• Joseph Lillegard M.D./w88 online gameD.
• Cile Savoy M.S.
• Tracy MacGill w88 online gameD.
• Sherri Bloomer M.S.
• Matthew Grinsell M.D./w88 online gameD.
• Ann Perceval M.S.
• Marjorie Sutherland w88 online gameD.
• Maria Parepalo w88 online gameD.
• Sindy Chavez w88 online gameD.
• Mark Hubbard w88 online gameD.
• Breeana Hubbard w88 online gameD.
• Joshua Rumfield M.S.

Education

• 1971: w88 online gameD., Microbiology, University of Iowa
  
• 1969: M.S., Microbiology, w88 online game Iowa
  
• 1967: B.A., Microbiology, w88 online game Iowa