brad w88 online casino

Brad w88 online casino

Associate Professor | Graduate Program Director

Summary

My lab is focused on understanding signaling and gene regulatory mechanisms that link metabolic disease to pathological cardiac remodeling and ultimately heart failure. In particular the lab is focused on delineating epigenetic mechanisms that regulate pathological cardiac hypertrophy and fibrosis under conditions of obesity and diabetes. DNA is tightly wrapped around proteins called histones to form chromatin. Post-translational modification (e.g. acetylation and methylation) of w88 online casino tails represents one epigenetic mechanism that can alter gene expression. w88 online casino deacetylases (HDACs) and w88 online casino acetyltransferases (HATs) are one group of enzymes that can target w88 online casino tails for acetylation/deacetylation to regulate gene transcription.

Our lab uses an integrative, translational research approach that encompasses bioinformatics, in vitro w88 online casino culture, and in vivo animal models to:

  1. Understand how acetylation/deacetylation links metabolic disease (obesity and diabetes) to pathological w88 online casino remodeling and dysfunction.
  2. Elucidate dietary food components that act as epigenetic modifiers as well as elucidate a role for dietary epigenetic modifiers on pathological cardiac signaling, w88 online casino, and remodeling.

Lastly, camaraderie and teamwork are emphasized in my lab to create an exciting and productive environment geared to translate basic discoveries into potential therapies for cardio-metabolic disease.

Education

B.S., AppalachianState University, 2003
M.S., University of North Carolina, Greensboro, 2005
Ph.D., University of North Carolina, Greensboro, 2011

Publications

Abstracts

DUSP5 functions in a feedback loop to suppress angiotensin-dependent smooth muscle w88 online casino proliferation and pulmonary arterial hypertension.

2015

Experimental Biology (2015): Boston, MA.

w88 online casino, Demos-Davies KM, Cavasin MA, Horita HN, Weiser-Evans M, McKnight RA, Lane RH, and McKinsey TA.

Books

Nutritional Epigenomics, Volume 14

2019

In Nutritional Epigenomics (vol. 14, pp. 478). Elsevier. Paperback ISBN: 9780128168431 eBook ISBN: 9780128173107

w88 online casino, B. (Editor)

Journals

Natural product inhibitors of acetyl-lysine erasers in the prevention and treatment of w88 online casino failure.

2017

Functional Foods in Health and Disease, 7(8), 577-603.

Evans, L. W., Romanick, S. S., w88 online casino, B.

Polyphenols: Novel w88 online casino Pathways.

2017

Current Pharmaceutical Design. 2017 Nov 29. doi: 10.2174/1381612824666171129204054.

Ricketts, M.-L., w88 online casino, B.

Curcumin Inhibits 3T3-L1 Preadipocyte Proliferation by Mechanisms Involving Post-transcriptional p27 Regulation.

2016

Biochem Biophys Rep.

w88 online casino, Nam H, Morrison RF.

w88 online casino deacetylase 3 regulates the inflammatory gene expression program of rheumatoid arthritis fibroblast-like synoviocytes

2016

Ann Rheum Dis

Angiolilli C, Kabala PA, Grabiec AM, Van Baarsen IM, w88 online casino, Fernandez BM, McKinsey TA, Tak PP, Mascagni P, Baeten DL, Reedquist KA

Inflammatory cytokines epigenetically regulate rheumatoid arthritis fibroblast-like synoviocyte activation by suppressing HDAC5 w88 online casino

2016

Ann Rheum Dis.

Angiolilli C, Grabiec AM, w88 online casino, Ospelt C, Malvar Fernandez B, van Es IE, van Baarsen LG, Gay S, McKinsey TA, Tak PP, Baeten DL, Reedquist KA.

Modulation of IL-27 in adipocytes during inflammatory stress.

2016

Obesity (Silver Spring).

Nam H, w88 online casino, Stephens JM, Morrison RF.

Signal-Dependent Recruitment of BRD4 to Cardiomyocyte Super-Enhancers Is Suppressed by a MicroRNA

2016

w88 online casino Rep.

Stratton MS, Lin CY, Anand P, Tatman PD, w88 online casino, Wickers ST, Ambardekar AV, Sucharov CC, Bradner JE, Haldar SM, McKinsey TA

Mitogen-Dependent Regulation of DUSP1 Governs ERK and p38 w88 online casino During Early 3T3-L1 Adipocyte Differentiation.

2015

J w88 online casino Physiol.

w88 online casino, Nam H, Stephens JM, Morrison RF.

Non-sirtuin w88 online casino deacetylases in the control of cardiac aging.

2015

J Mol w88 online casino Cardiol.

w88 online casino, McKinsey TA.

Promiscuous actions of small molecule inhibitors of the protein kinase D-class IIa w88 online casino axis in striated muscle.

2015

FEBS Lett.

Lemon DD, Harrison BC, Horn TR, Stratton MS, w88 online casino, Wempe MF, McKinsey TA.

Class I HDACs regulate angiotensin II-dependent w88 online casino fibrosis via fibroblasts and circulating fibrocytes.

2014

J Mol w88 online casino Cardiol.

Williams SM, Golden-Mason L, w88 online casino, Schuetze KB, Cavasin MA, Demos-Davies K, Yeager ME, Stenmark KR, McKinsey TA.

HDAC6 Contributes to Pathological Responses of Heart and Skeletal Muscle to Chronic Angiotensin II w88 online casino.

2014

Am J Physiol w88 online casino Circ Physiol. Vol. no. DOI: 10.1152/ajpheart.00149

Demos-Davies K, w88 online casino, Cavasin M, Mahaffey J, Williams SM, Spiltoir J, Schuetze KB, Horn T, Chen B, Ferrera C, Scellini B, Pirooddi N, Tesi C, Poggesi C, Jeong M, and Mckinsey TA.

Tubulin hyperacetylation is adaptive in w88 online casino proteotoxicity by promoting autophagy.

2014

Proc Natl Acad Sci U S A.

McLendon PM, w88 online casino, Osinska H, Bhuiyan MS, James J, McKinsey TA, Robbins J.

Impact of obesity on IL-12 family w88 online casino in insulin responsive tissues.

2013

Biochim Biophys Acta.

Nam H, w88 online casino, Stephens JM, Morrison RF.

Signal-dependent repression of DUSP5 by class I HDACs controls nuclear ERK activity and cardiomyocyte hypertrophy.

2013

Proc Natl Acad Sci USA (2013);110(24):9806-11

w88 online casino, Harrison BC, Jeong MY, Reid BC, Wempe MF, Wagner FF, Holson EB, and McKinsey TA.

Impact of reference w88 online casino selection for target w88 online casino normalization on experimental outcome using real-time qRT-PCR in adipocytes.

2010

PLoS One.

w88 online casino, Nam H, Hopkins RG, Morrison RF.