Department of Biochemistry & Molecular w88 online game

Mitchell w88 online game

Assistant Professor, w88 online game and Disease

Department: Department of w88 sports betting & Molecular
Main Office: (775) 784-1327
Email: momar@unr.edu
Building: HMS
Room: 154
Mailstop: 330

Summary

My interests focus on w88 online game organization in human health and disease. With a billion proteins packed into a cell, cross-talk and non-specific interactions should dominate. However, cells have evolved subcellular organizational strategies to overcome this. Two crucial strategies are protein complexes and subcellular recruitment.

How do w88 online game complexes provide the spatial and temporal compartmentalization needed to accomplish cellular processes?

How do mutations that disrupt this organization cause w88 online game?

Our current efforts are working to understand the molecular events and regulatory elements that underlie stress hormone production by the adrenal glands. Other projects will investigate how protein kinase A regulation impacts tumor growth and neuronal function. Commonly used techniques include classic molecular w88 online game and cell culture as well as live-cell fluorescent imaging, proximity proteomics, and CRISPR gene-editing. Ultimately, the Omar lab intends to reveal cellular and molecular mechanisms governing vital physiology and to identify new strategies to ameliorate and prevent human disease.

Education

B.A. English, Minnesota State University Moorhead, 2007
B.S. w88 online game, University of Iowa, 2011
Ph.D. Neuroscience, Yale University, 2017

Publications

Book Chapter(s)

Biochemical Analysis of AKAPanchored PKA Signaling w88 online game

2022

Methods in Molecular w88 online game (Clifton, NJ). cAMP Signaling: Methods and Protocols, Second Edition. Manuela Zaccolo, ed.

Byrne D.P., w88 online game M.H., Kennedy E.J., Eyers P.A., Scott J.D.

Journals

Discovery of a Cushing’s syndrome w88 online game A mutant that biases signaling through type I AKAPs

2024

Science Advances, Vol. 10 Issue 8

Mitchell H. w88 online game, Dominic P. Byrne, Safal Shrestha, Tyler M. Lakey, Kyung-Soon Lee, Sophia M. Lauer, Kerrie B. Collins, Leonard A. Daly, Claire E. Eyers, Geoffrey S. Baird, Shao-En Ong, Natarajan Kannan, Patrick A. Eyers, John D. Scott

Recruitment of BAG2 to DNAJ-PKAc scaffolds promotes w88 online game survival and resistance to drug-induced apoptosis in fibrolamellar carcinoma

2024

w88 online game, Vol. 43 Issue 2

Lauer, S.M., w88 online game, M.H., Golkowski M., Kenerson H.L., Pascual B.C., Forbush K., Smith F.D., Gordon J., Ong S.-E., Yeung R.S., Scott J.D

Classification of Cushing’w88 online game PKAc mutants based upon their ability to bind PKI.

2023

Biochemical Journal 480(12):875-890

w88 online game M.H.*, Kihiu M.* (*co-first authors), Byrne D.P., Lee K.-S., Lakey T.M., Butcher E., Eyers P.A., Scott J.D.

Proximity biotinylation to define the local environment of the w88 online game A catalytic subunit in adrenal cells

2023

STAR Protocols 4(1):101992

w88 online game M.H., Lauer S.M., Lau H.-T., Golkowski M., Ong S.-E., Scott J.D.

Mislocalization of w88 online game A drives pathology in Cushing’s syndrome

2022

w88 online game 40. 10.1016

w88 online game M.H., et.al.

Targeting an anchored phosphatase-deacetylase unit restores renal ciliary homeostasis

2021

eLife 10, e67828

Gopalan J., w88 online game M.H., Roy A., Cruz N.M., Falcone J., Jones K.N., Forbush K.A., Himmelfarb J., Freedman B.S., Scott J.D.

AKAP Signaling Islands: Venues for Precision Pharmacology

2020

Trends in Pharmacological Sciences 41, 933-946

w88 online game M.H., Scott J.D.

An acquired scaffolding function of the DNAJ-PKAc fusion contributes to oncogenic signaling w88 online game.

2019

eLife 8:e44187

Turnham R.E., Smith F.D., Kenerson H.L., w88 online game M.H., Golkowski M., Garcia I., Bauer R., Lau H.-T., Sullivan K.M., Langeberg L.K., Ong S.-E., Riehle K.J., Yeung R.S., Scott J.D.

Single nucleotide polymorphisms alter w88 online game anchoring and the subcellular targeting of A-w88 online game anchoring proteins.

2018

PNAS, 115 (49) E11465-E11474

Smith F.D., w88 online game M.H., Nygren P.J., Soughayer J., Hoshi N., Lau H.-T., Snyder C.G., Branon T.C., Ghosh D., Langeberg L.K., Ting A.Y., Santana L.F., Ong S.-E., Navedo M.F., Scott J.D.

CNS Neurons Deposit Laminin a5 to Stabilize Synapses

2017

w88 online game

w88 online game, M.H., Campbell, M.K., Xiao, X., Zhong, Q., Brunken, W.J., Miner, J.H., Greer, C.A., and Koleske, A.J.

Corticosteroid-induced dendrite loss and behavioral deficiencies can be blocked by activation of Abl2/Arg w88 online game.

2017

w88 online game and Cellular Neuroscience

Shapiro L.P.*, w88 online game M.H.* (*co-first authors), Koleske A.J., Gourley S.L.

Long-Term Live-w88 online game STED Nanoscopy of Primary and Cultured Cells with the Plasma Membrane HIDE Probe DiI-SiR.

2017

Angewandte Chemie

Thompson A.D., w88 online game M.H., Rivera-Molina F., Xi Z., Koleske A.J., Derek Toomre D., Schepartz A.

Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2.

2016

Journal of Clinical Investigation

Matsumoto Y., La Rose J., Kent O.A., Wagner M.J., Narimatsu M., Levy A.D., w88 online game M.H., Tong J., Krieger J.R., Riggs E., Storozhuk Y., Pasquale J., Ventura M., Yeganeh B., Post M., Moran M.F., Grynpas M.D., Wrana J.L., Superti-Furga G., Koleske A.J., Pendergast A.M., Rottapel R.

Extracellular matrix control of dendritic spine and synapse structure and plasticity in adulthood.

2014

Frontiers in Neuroanatomy

Levy A.D.*, w88 online game M.H.* (*co-first authors), Koleske, A. J.