Role w88 sports betting app signaling GTPase dynamin in coordinating endocytosis with other cellular functions to maintain homeostasis. That is, as a vesicle (small bubble enclosed by cellslipid bilayer)invaginates, dynamin forms a spiral around the neck w88 sports betting app vesicle. Once the spiral is in place, it extends lengthwise and constricts through GTP hydrolysis. This lengthening and tightening w88 sports betting app coil around the vesicle neck causes it to break and results in the pinching off w88 sports betting app vesicle from the parent membrane.

Our research aims at the biochemical characterization of recently identified mutations within w88 sports betting app that have been associated with neuromuscular diseases.

My research and others have provided further evidence that dynamin is multi-functional, with the potential to regulate diverse aspects of cellular function: The isoform w88 sports betting app2 is associated with selective sites of actin rearrangements where it recruits proteins known to regulate actin assembly. We provided one of the first lines of evidence that w88 sports betting app2 specifically acts as a signaling component that controls entry into an apoptosis pathway. w88 sports betting app2, but not w88 sports betting app1, can induce apoptosis when expressed as little as 2-fold over the endogenous level. This response is dependent on the presence of functional p53, a tumor suppressor and transcriptional regulator, suggesting a role for dynamin as signaling GTPase in response to cell stress. My goal is to use this w88 sports betting app2 specific phenotype to understand how this multi-functional enzyme links endocytic events to signal transduction, rearrangements of the actin cytoskeleton, cell proliferation and apoptosis. With cell biological, biochemical and profiling approaches we will gain valuable insights into these fundamental questions relevant to cancer biology.