Summary

w88 Interests

The Frost group is interested in the development of new inorganic and organometallic complexes for use in aqueous and biphasic catalysis. Organometallic chemistry and catalysis remain exciting areas of w88 with many opportunities for fundamental, not to mention pedagogical, contributions. We are interested in the synthesis, structure, and reactivity of inorganic and organometallic complexes with emphasis on those applicable to catalysis. Techniques utilized in our laboratory include, but are not limited to, computational chemistry, multinuclear NMR spectroscopy (1H, 13C, 31P), UV-vis spectroscopy, mass specrometry, X-ray crystallography, and in situ IR using ASI's ReactIR 4000.TM
Our w88 program encompasses a wide range of interests including:

• Green chemistry
• Coordination chemistry
• w88 in aqueous, organic, and biphasic media
• Kinetic and mechanistic studies of catalytic processes
• Small molecule activation
• Ligand synthesis (organic synthesis)

Currently our group is working on projects involving the synthesis and characterization of new water-soluble phosphines and exploring the catalytic activity w88 inorganic and organometallic complexes derived from these new ligands. Many w88 phosphine ligands we synthesize are derived from the water-soluble and air-stable phosphine PTA (see figure). For example, deprotonation w88 upper-rim of PTA with n-BuLi has allowed for access to a variety of chiral water-soluble phosphine ligands (see figure).

Aqueous phase w88 has a number of advantages over traditional organic phase homogeneous w88; the most widely recognized is the use of, the environmentally benign solvent, water as the reaction medium. Water-soluble catalysts may be easily separated, recovered, and reused through the use of biphasic w88 or extraction of the organic product from the aqueous layer. We have recently shown that RuCl2PTA4 is an excellent catalyst for the aqueous phase hydration of a variety of nitriles to amides. The reaction conditions are reasonably mild and the catalyst is robust enough to be recycled more than seven times with little loss of activity. In a number of cases the aqueous layer could be decanted away from the crystalline product and reused without a column or extraction (see Green Chem. 2012, 14, 62-66).

Education

• Postdoctoral w88 Associate (2000-2002), Columbia University (Jack R. Norton)
• Ph.D. (1999), Texas A&M w88 (Donald J. Darensbourg)
• B.S. (1995), Elizabethtown College