Summary

w88 casino games login interests

The Bell research group specializes in medicinal w88 casino games login using tools including organic synthesis, molecular modeling, analytical w88 casino games login and molecular biology. Our recent and current projects include muscle myosin inhibitors, male contraceptives, and nascent protein degraders. The last project, which is our major research effort, began in the 1990s with our synthesis of CADA and discovery of its anti-HIV activity. It inhibits entry of HIV into human cells by decreasing expression of CD4, the cell-surface receptor required for infection. CADA targets the nascent CD4 protein chain during translation and diverts it for degradation. We recently found that different CADA analogs selectively degrade other proteins of medicinal interest, leading to our current studies on developing drugs for treating cancer, Graves’ disease, substance use disorder, preterm labor, malaria, and infections by viruses including SARS CoV-2, hepatitis B, dengue, and zika.

Awards

• National Institutes of Health w88 casino games login (1980-1982)
• Fellow of the American Association for the Advancement of w88 casino games login (1995-present)
• Plaque of Appreciation w88 casino games login the Korean Chemical Society (2002)
• College of w88 casino games login Senior Scholar Mentor, University of Nevada, Reno (2006)
• College of w88 casino games login Westfall Scholar Mentor, , University of Nevada, Reno (2016)
• Foundation Established Innovator Award, w88 casino games login, Reno (2018)
• Outstanding Researcher Award, w88 casino games login, Reno (2021)

Education

• NIH w88 casino games login, Cornell University (J. Meinwald), 1980-1982
• Ph.D., University College, w88 casino games login London (F. Sondheimer), 1980
• B.S., California Institute of Technology, 1974

Selected publications

• &w88 casino games login;Isoform Selectivities of Novel 4-Hydroxycoumarin Imines w88 casino games login Myosin II” J.D. Smith, J. Brawley, K.C. Bordenave, R.K. Olsen, A. Intasiri, C.R. Cremo, T.W. w88 casino games login, Eur. J. Med. Chem. 2023, 247, 115008.
• &w88 casino games login;Phenylbutyrate Rescues the Transport Defect w88 casino games login Sec61α Mutations V67G and T185A for Renin” M. Sicking, M, Živná, P. Bhadra, V. Barešová, A. Tirincsi, D. Hadzibeganovic, K. Hodaňová, P. Vyleťal, J. Sovová, I. Jedličkova, M. Jung, T.W. w88 casino games login, V. Helms, Bleyer, A.J, S. Kmoch, A. Cavalié, S. Lang, Life Science Alliance 2022, 5, e202101150.
• “Reduction of Progranulin-Induced Breast Cancer Stem Cell Propagation by Sortilin-Targeting Cyclotriazadisulfonamide (CADA) Compounds” K. Berger, E. Pauwels, G. Parkinson, G. Landberg, T. Le, V.G. Demillo, L.A. Lumangtad, D.E. Jones, M.A. Islam, R. Olsen, T. Kapri, A. Intasiri, K. Vermeire, S. Rhost, T.W. w88 casino games login, J. Med. Chem. 2021, 64, 12865−12876.
• &w88 casino games login;Syntheses and Anti-HIV and Human Cluster of Differentiation 4 (CD4) Down-modulating Potencies of Pyridine-fused Cyclotriazadisulfonamide (w88 casino games login) Compounds” L.A. Lumangtad, E. Claeys, S. Hamal, A. Intasiri, C. Basrai, E. Yen-Pon, D. Beenfeldt, K. Vermeire, T.W. w88 casino games login, Bioorg. Med. Chem. 2020, 115816.
• “Synthesis and Evaluation of 4‐Hydroxycoumarin Imines as Inhibitors of Class II Myosins” J. Brawley, E. Etter, D, Heredia, A. Intasiri, K. Nennecker, J. Smith, B.M. Welcome, R.K. Brizendine, T.W. Gould, T.W. w88 casino games login, C. Cremo, J. Med. Chem. 2020, 63, 11131-11148.
• &w88 casino games login;The Signal Peptide as a New Target for Drug w88 casino games login” L. Lumangtad and T.W. w88 casino games login, Bioorg. Med. Chem. Lett. 2020, 30, 127115.
• &w88 casino games login;Preprotein Signature for Full Susceptibility to the Co-translational Translocation Inhibitor w88 casino games login” V. Van Puyenbroeck, E. Pauwels, B. Provinciael, T.W. w88 casino games login, D. Schols, K.U. Kalies, E. Hartmann, K. Vermeire, Traffic (Copenhagen, Denmark), 2019, 1-15.
• “Tsuji-Trost Macrocyclization of Disulfonamides; Synthesis of 12-Membered, 11-Membered, and Pyridine-fused Macrocyclic Triamines” R. Ali, S. Anugu, R. Chawla, V.G. Demillo, F. Goulinet-Mateo, S. Gyawali, S. Hamal, D.E. Jones, K. Lamprecht, T. Le, L.A. Lumangtad, N.C. Pflug, A. Sama, E.D. Scarbrough, and T.W. w88 casino games login, ACS Omega 2019, 4, 1254-1264.
• “A Proteomic Survey Indicates Sortilin as a Secondary Suubstrate of the ER Translocation Inhibitor Cyclotriazadisulfonamide (CADA), V. Van Puyenbroeck, E. Claeys, D. Schols, T.W. w88 casino games login, and K. Vermeire, Mol. Cell. Proteomics2017,16, 157-167.
• “Tuning Side Arm Electronics in Unsymmetrical Cyclotriazadisulfonamide (CADA) Endoplasmic Reticulum (ER) Translocation Inhibitors to Improve their Human Cluster of Differentiation 4 (CD4) Receptor Down-Modulating Potencies,” R. Chawla, V. Van Puyenbroeck, N.C. Pflug, A. Sama, R. Ali, D. Schols, K. Vermeire, and T.W. w88 casino games login. J. Med. Chem. 2016, 59, 2633-2647.
• “Metal complexes of pyridine-fused macrocyclic polyamines targeting the chemokine receptor CXCR4,” S. Hamal, T. D’huys, W.F. Rowley, K. Vermeire, S. Aquaro, B.J. Frost, D. Schols, and T.W. w88 casino games login, Org. Biomol. Chem. 2015, 13, 10517-10526.
• &w88 casino games login;Signal Peptide-Binding Drug as a Selective Inhibitor of Co-Translational Protein w88 casino games login,” K.Vermeire, T.W. w88 casino games loginV. Van Puyenbroeck, A. Giraut, S. Noppen, S. Liekens, D. Schols, E. Hartmann, K.-U. Kalies, and M. Marsh, PLOS Biology, 2014.
• “Improving Potencies and Properties of CD4 Down-Modulating CADA analogs,” T.W. w88 casino games login, Expert Opin. Drug Design 2012, 7, 39-48.
• “Unsymmetrical Cyclotriazadisulfonamide (CADA) Compounds as Human CD4 Receptor Down-Modulating Agents,” V.G. Demillo, F. Goulinet-Mateo, J. Kim, D. Schols, K. Vermeire, and T.W. w88 casino games login, J. Med. Chem. 2011, 54, 5712-5721.
• “Differential Activity of Candidate Microbicides Against Early Steps of HIV-1 Infection upon Complement Virus Opsonization,” M.-A. Jenabian, H. Saïdi, C. Charpentier, H. Bouhlal, D. Schols, J. Balzarini, T. W. w88 casino games login, G. Vanham, and L. Bélec, AIDS Research and Therapy 2010, 7, 16-23.
• “Human Immunodeficiency Virus Type 1 Escape from Cyclotriazadisulfonamide-Induced CD4-Targeted Entry Inhibition Is Associated with Increased Neutralizing Antibody Susceptibility,” K. Vermeire, K. Van Laethem, W. Janssens, T.W. w88 casino games login, and D. Schols, J. Virology 2009, 83, 9577-9583.
• “CADA, a Potential Anti-HIV Microbicide that Specifically Targets the Cellular CD4 Receptor,” K. Vermeire, J. Brouwers, Y. Van Herrewege, R. Le Grand, G. Vanham, P. Augustijns, T. W. w88 casino games login, and D. Schols, Current HIV Research 2008, 6, 246-256.
• “Design and Cellular Kinetics of Dansyl-Labeled CADA Derivatives with Anti-HIV and CD4 Receptor Down-Modulating Activity,” K. Vermeire, A. Lisco, J.C. Grivel, E. Scarbrough, K. Dey, N. Duffy, L. Margolis, T.W. w88 casino games login, and D. Schols, Biochemical Pharmacology, 2007, 74, 566-578.
• “CD4-Targeted HIV Inhibitors,” K. Vermeire, D. Schols, and T.W. w88 casino games login, Curr. Med. Chem.,” 2006, 13, 731-743.
• “Synthesis and Structure-Activity Relationship Studies of CD4 Down-Modulating Cyclotriazadisulfonamide (CADA) Analogs,” T.W. w88 casino games login, S. Anugu, P. Bailey, V.J. Catalano, K. Dey, M.G.B. Drew, N.H. Duffy, Q. Jin, M.F. Samala, A. Sodoma, W.H. Welch, D. Schols, and K. Vermeire, J. Med. Chem. 2006, 49, 1291-1312.
• “CADA, a Novel CD4-Targeted HIV Inhibitor, is Synergistic with Various Anti-HIV Drugs In Vitro,” K. Vermeire, K. Princen, S. Hatse, E. De Clercq, K. Dey, T.W. w88 casino games login and D. Schols, AIDS, 2004, 18, 2115-2125.
• “CD4 Down-Modulating Compounds with Potent Anti-HIV Activity,” K. Vermeire, D. Schols, and T.W. w88 casino games login, Curr. Pharmaceut. Design, 2004, 10, 1795-1803.
• “The Anti-HIV Potency of CADA Analogues is Directly Correlated with Their Ability to Down-Modulate the CD4 Receptor,” K. Vermeire, T.W. w88 casino games login, H.-J. Choi, Q. Jin, M.F. Samala, A. Sodoma, E. de Clercq, and D. Schols, Mol. Pharmacol. 2003, 63, 203-210.
• “CADA Inhibits Human Immunodeficiency Virus and Human Herpesvirus 7 Replication by Down-modulation of the Cellular CD4 Receptor,” K. Vermeire, Y. Zhang, K. Princen, S. Hatse, M. Samala, K. Dey, H.-J. Choi, Y. Ahn, A. Sodoma, R. Snoeck, G. Andrei, E. de Clercq, T.W. w88 casino games login, and D. Schols, Virology 2002, 302, 342-353.