Claus w88 casino

Claus w88 casino

Associate Dean of Academic Affairs

Summary

We use functional genomics, w88 casino biology, and biochemical techniques to understand bark beetles and their interactions with host trees. We are concentrating on two areas: the enzymes involved in isoprenoid pheromone biosynthetic pathways and the ability of the beetle to metabolize toxic resin components.

Pine bark beetles, while physically very small, can kill vast areas of coniferous forest during outbreak conditions. The increased forest fire risk and loss of timber are significant economic costs associated with bark beetle activity. Research in my lab focuses on understanding various aspects of the bark beetles’ w88 casino in order to better develop targeted control strategies. Our long term goal is to specifically regulate bark beetle populations, at least in an urban setting, without harming non-target organisms. There are two broad subject areas under study:

w88 casino Biosynthesis:Bark beetle outbreaks are mediated by aggregation pheromones, many of which are monoterpenes. Since de novo monoterpene synthesis in the Metazoa is rare, the w88 casino biosynthetic pathway is an attractive target for eventual control strategies. Monoterpenoid w88 casino components are synthesized in the midgut via the mevalonate (isoprenoid) pathway, with carbon likely being shunted away from the mevalonate pathway and into the w88 casino pathway at geranyl diphosphate.

Phloem Detoxification: Pine trees are full of toxic resin, which discourages animals from eating them. The resin contains mostly monoterpenoid solvents --turpentine and Pine-Sol are produced from pine trees-- and considering that drinking a medium-sized glass of turpentine is enough to kill most humans (not recommended, don’t try it!), it is remarkable that bark beetles can thrive in their environment. Since different beetle species are more or less restricted to their host tree species, their detoxification processes are probably “tuned” to their host tree. We are trying to understand the biochemical mechanisms the beetles use to survive constant monoterpene ingestion

Education

B.Sc. w88 casino, 1987 University of Ottawa
Ph.D. Biology, 1994 Queens University, Kingston, Ontario, Canada

Publications

Book Chapter(s)

Advances in Insect Physiology: w88 casino production in bark beetles.

2016

In C w88 casino and GJ Blomquist (Ed.), Advances in Insect Physiology (vol. 50, pp. 235-263). Advances in Insect Physiology/Elsevier.

w88 casino, C., Blomquist, G.

Pine Bark Beetles

2016

In w88 casino, C and Blomquist, GJ (Ed.), (pp. 304). Advances in Insect Physiology

w88 casino, C., Blomquist, G.

Journals

Mountain Pine Beetle (Dendroctonus ponderosae) CYP4Gs convert long and short chain alcohols and aldehydes to hydrocarbons.

2018

Insect Biochemistry and w88 casino Biology, 102, 11-20

MacLean, M., Gurnea, T., Nadeau, J., w88 casino, C., Blomquist, G. J.

Comparative transcriptomics of mountain pine beetle w88 casino-biosynthetic tissues and functional analysis of CYP6DE3.

2017

BMC Genomics, 18, 311.

Nadeau, J., Petereit, J., Tillett, R.J., Jung, K., Footoohi, M., MacLean, M., Young, S., Blomquist, G., w88 casino, C

Drosphila Spidey/Kar regulates oenocyte growth via P13-kinase signaling.

2016

PLOS GENETICS, 12(8), e1006154

Cinnamon, E., Makki, R., Sawala, A., Wickenberg, L., Huestis, D., Blomquist, G., w88 casino, C., Paroush, Z., Gould, A.

Frontalin w88 casino biosynthesis in the mountain pine beetle, Dendroctonus ponderosae Hopkins, role of isoprenyldiphosphate synthases.

2013

Proceedings of the National Academy of Sciences, 110, 18838-18843.

Keeling, C. K., Chiu, C. C., Aw, T., Li, M., w88 casino, C., Weng, H., Blomquist, G., Bohlman, J.

An insect-specific P450 oxidative decarnonylase for cuticular hydrocarbon biosynthesis.

2012

Proceedings of the National Academy of Sciences, U.S.A., 109(37), 14853-14863.

Qiu, Y., w88 casino, C., Wicker-Thomas, C., LeGoff, G., Young, S., Wajnberg, E., Fricaux, T., Taquet, N., Blomquist, G. J., Feyereisen, R.

Ipsdienol dehydrogenase (IDOLDH): a novel oxidoreductase important for Ips pini w88 casino production.

2012

Insect Biochem Mol Biol. 2012 Feb;42(2):81-90.

Figueroa-Teran R, Welch WH, Blomquist GJ, w88 casino C.

w88 casino production in bark beetles.

2010

Insect Biochemistry and w88 casino Biology, 40, 699-712.

Blomquist, G., Figueroa-Teran, R., Aw, M., Song, M., Gorzalski, A., Abbott, N. L., Chang, E., w88 casino, C.

Isolation and characterization of farnesyl diphosphate synthase from the cotton boll weevil, Anthonomus grandis.

2009

Archives of Insect w88 casino and Physiology, 71(2), 88-104.

Taban, H., w88 casino, C., Blomquist, G., Welch, W. H.

Two regulatory mechanisms of monoterpenoid w88 casino production in Ips spp. of bark beetles.

2009

J. Chemical Ecology, 35, 689-697.

Bearfield, J. C., Henry, A. G., w88 casino, C., Blomquist, G., Ginzel, M. D.

<divBark beetles use aggregation pheromones to coordinate host colonization and mating.&nbsp;These monoterpenoid chemical signals are produced de novo in midgut cells via the mevalonate pathway, and...

Unique animal prenyltransferase with monoterpene synthase activity.

2009

Naturwissenschaften, 96, 731-735.

Gilg, A. B., w88 casino, C., Blomquist, G.

Some insights into the remarkable metabolism of the bark beetle midgut

2005

Recent Adv. Phytochem. 39, 57-78

C. w88 casino, C. I. Keeling and G. J. Blomquist

Proceedings

Cytochromes P450 associated with insecticide resistance catalyse cuticular hydrocarbon production in Anopheles gambiae.

2016

Proceedings of the National Academy of Sciences, USA, 113(33), 9268-9273.

Balibanidou, V., Kambouraki, A., MacLean, M., Blomquist, G. J., w88 casino, C., Juarez, M., Mijailovsky, S., Chalepakis, G., Anthousi, A., Hemmingway, J., Antoine, S., Lynd, A., Lycett, G., Vontas, J.