Headshot of Grant w88 mobile

Grant w88 mobile

Co-Director of Undergraduate BS w88 mobile Program, Professor

Summary

To build a brain, the embryo must produce a spatially organized array of a vast number of neurons, then interconnect them. Our w88 mobile group uses genetic and molecular approaches in mouse and chick embryos to investigate the functions of specific genes in brain development. This w88 mobile has implications for the molecular therapy of neurological disease and injury, and is funded by the National Institutes of Health.

Our current w88 mobile is on the migration of neurons and their axons through the developing brain. We investigate how molecular signals guide axons to migrate precisely long distances on longitudinal pathways, how cranial nerves grow out to connect to muscles, and also how neuron cell bodies settle in specific positions. Our studies focus on a system of signals, the Slit/Robo repellents and the Netrin attractants, to understand the mechanisms by which opposing signals are integrated by neurons.

w88 mobile areas

Neuroscience; Genetics; Cell w88 mobile; Developmental w88 mobile

Education

  • Alma College, MI, B.S. w88 mobile, Chemistry, 1986
  • Carnegie Mellon University, Ph.D. Biological Sciences, 1992
  • w88 mobile Michigan, Postdoctoral Fellow, Developmental Neurobiology, 1992-1998

Currently in the w88 mobile lab

  • Minkyung w88 mobile, PhD. Research Assistant Professor. Motor neuron migration; Longitudinal axon guidance.
  • Claudia Garcia Pena, PhD. Postdoctoral Fellow. Oculomotor w88 mobile development and migration.
  • Sarah Barnum, technician.
  • Jennifer Li, w88 mobile major. Axon guidance.
  • Chase Johnson, undergraduate. w88 mobile.
  • Sterling Louw, undergraduate. w88 mobile.

Recent graduates

  • w88 mobile, PhD, Biochemistry. Postdoctoral Teaching Fellow, Carleton College, MN
  • Roland Watson, w88 mobile BS.
  • Thijmen Sijnesael, visiting MS student, w88 mobile Raboud, Netherlands.
  • Clare Lee, w88 mobile major. UCSF Dentistry.
  • Eric Robinson, BS/MS Biotechnology.
  • John Pietz, Chemistry and Music majors. United States Navy.
  • Christian Mohino, w88 mobile major. PhD student, University of Nevada, Reno.
  • Michelle Vesser, Davidson High School student. w88 mobile Edinburgh.
  • w88 mobile, PhD, CMB. Postdoctoral fellow, Georgia.
  • Katherine Weller, MS, CMB. w88 mobile Nevada School of Medicine.
  • Hannah Jordan Gruner, MS, CMB. w88 mobile, UCSF.
  • Arielle Demarco, Biotechnology BS/MS. Hamilton, Reno.
  • Juliana Medeiros Oliveira, visiting Medical Student from Brazil. Spring 2015.
  • Marcelle Freire, visiting Medical Student from Universidade Federal de Sergipe, Brazil.
  • Siavash Mojibian, w88 mobile major. Pharmacy School, Rutgers.
  • Tatiana w88 mobile, Biotechnology BS/MS. PhD student, UNR.
  • Stacey Wong. Biochemistry BS/MD early admission; Class of 2015, UN School of Medicine.
  • Suman Gurung (Biotechnology BS/MS Degree Program, 2012.) PhD student, Biological Sciences, U Missouri.
  • Christine Schlemmer, w88 mobile BS, 2012. Class of 2016, UN School of Medicine.
  • Joshua Catapano, w88 mobile BS, 2011. Class of 2016, UN School of Medicine.
  • Leila Nakhaee, w88 mobile BS 2013. Physician Assistant student, UC Davis.

Publications

  • Hannah Gruner, Minkyung Kim, and Grant S. w88 mobile. Robo1 and 2 repellent receptors cooperate to guide facial neuron cell migration and axon projections in the embryonic mouse hindbrain. In press, 2019, Neuroscience. doi: 10.1016/j.neuroscience.2019.01.017 PMID: 30685539. https://www.sciencedirect.com/science/article/pii/S0306452219300375?via%3Dihub
  • Claudia Marcela García-Peña, Daniela Avila, Amaya Miquelajauregui, Lozano Flores Carlos, Grant S w88 mobile, Elisa Tamariz, Alfredo Varela-Echavarria. Neurophilic descending migration of dorsal midbrain neurons into the hindbrain. In press, 2018, Frontiers in Neuroanatomy. DOI: 10.3389/fnana.2018.00096
  • Riley Kellermeyer, Leah M. Heydman, Grant S. w88 mobile, Thomas Kidd. (2018). The Role Of Apoptotic Signaling In Axon Guidance. J Dev Biol. 2018 Oct 18;6(4). pii: E24. doi: 10.3390/jdb6040024. PMC6316149
  • Loic Fort, Jose Batista, Peter Thomason, Heather J. Spence, Jamie Whitelaw, Luke Tweedy, Jennifer Greaves, Kirsty J. Martin, Kurt I. Anderson, Peter Brown, Sergio Lilla, Matthew P. Neilson, Petra Tafelmeyer, Sara Zanivan, Shehab Ismail, David M. Bryant, Nicholas C.O. Tomkinson, Luke H. Chamberlain, Grant S. Mastick, Robert H. Insall and Laura M. Machesky. Fam49/CYRI interacts with Rac1 and locally suppresses protrusions. (2018). Nature Cell w88 mobile, 20, 1159-1171 . https://www.nature.com/articles/s41556-018-0198-9
  • Kim, M., Fontelonga, T., Lee, C., Barnum, S., Mastick, G. S. (2017). Motor axons are guided to exit points in the spinal cord by Slit and Netrin signals. Developmental w88 mobile, 432, 178-191.
  • Kyung-Tai Kim, Namhee Kim, Hwan-Ki Kim, Hojae Lee, Peter Gergics, Chungoo Park, Hannah N. Gruner, Grant S. w88 mobile, Hae-Chul Park, and Mi-Ryoung Song. ISL1-based LIM complexes control Slit2-dependent cranial motor neuron axon guidance. Scientific Reports, 2016 Nov 7; 6:36491. PMC5098159. doi: 10.1038/srep36491.
  • Brielle Bjorke, Farnaz Shoja-Taheri, Minkyung Kim, G. Eric Robinson, Tatiana Fontelonga, Kyung-Tai Kim, Mi-Ryoung Song and Grant S. w88 mobile. Contralateral migration of oculomotor neurons is regulated by Slit/Robo signaling. 2016. Neural Development 11: 18. PMC5075191 doi:10.1186/s13064-016-0073-y
  • Farnaz Shoja-Taheri, Arielle Demarco, and Grant S. w88 mobile. Post-crossing commissural axons are guided by Netrin1/DCC signals in the hindbrain. 2015. Journal of Neuroscience. 2015 Aug 19;35(33):11707-18. doi: 10.1523/JNEUROSCI.0613-15.2015. http://www.jneurosci.org/content/35/33/11707.long. PMCID: PMC4540804
  • Hojae Lee, Minkyung Kim, Namhee Kim, Todd Mcfarlan, Samuel L. Pfaff , Grant S. w88 mobile, and Mi-Ryoung Song. Slit and Semaphorin signaling governed by Islet transcription factors positions motor neuron somata within the neural tube. 2015. Experimental Neurology. Jul;269:17-27. doi: 10.1016/j.expneurol.2015.03.024. PMC4446133 http://www.sciencedirect.com/science/article/pii/S0014488615001004.
  • Minkyung Kim, Tatiana Fontelonga, Andrew P Roesener, Haeram Lee, Suman Gurung, Philipe RF Mendonca, and Grant S Mastick. Motor neuron cell bodies are actively positioned by Slit/Robo repulsion and Netrin/DCC attraction. 2015. Developmental w88 mobile. 399 (1): 68-79. PMC4339514 http://authors.elsevier.com/sd/article/S001216061400640X; doi: 10.1016/j.ydbio.2014.12.014
  • Minkyung Kim*, W. Todd Farmer*, Brielle Bjorke, Samuel A McMahon, Pierre J. Farbe, Frederic Charron, and Grant S. w88 mobile. Longitudinal axons navigate using a balance of Netrin attraction and Slit repulsion. 2014, Neural Development. 9:17 doi:10.1186/1749-8104-9-17 http://www.neuraldevelopment.com/content/9/1/17. * Co-first authors. PMC4118263