Summary

I joined the Department of w88 online casino betting at UNR in 1987, where I developed and taught courses in Cell and Molecular w88 online casino betting for undergraduate non-science majors, w88 online casino betting majors, and graduate students. I found that teaching molecular cellular w88 online casino betting was a challenge due to the exponential growth of knowledge in this field, yet working with the many bright students in my classes was extremely rewarding. For my teaching efforts I twice received nominations for the Board of Regents' University Teaching Award, twice was a finalist for the College of A&S Teaching Excellence Award, and was also a College of Science Outstanding Teaching award finalist. In 2000, I developed an accelerated combined BS/masters degree program in Biotechnology, in 2002, I was awarded the University of Nevada Foundation Professorship, and in 2005, I was identified as a Senior Scholar Mentor.

During my tenure at the w88 online casino betting Nevada, Reno, my research program was supported by grants and awards from UNR, Reno Cancer Center, ACS, Cystic Fibrosis Foundation, NIH, and NSF. Among these, was a career development award supporting a summer research fellowship at UC Berkeley with Randy Schekman and a sabbatical at the w88 online casino betting Melbourne with M-J Gething. Additional international research seminars, research collaborations, and teaching courses in protein trafficking, took me to Spain, Hong Kong, Russia, Australia, Slovenia, Croatia, New Zealand, three universities in South Africa, and several universities in the USA. Together with graduate students, postdoctoral fellows, international collaborators, and undergraduate research students, we published 32 scientific papers in refereed journals, 3 book chapters, 57 abstracts in conference and symposium proceedings, and numerous invited reviews, reports, and news articles.

As a scientific advisor, I benefitted from assignments at the Finish Academy of Science, Israel Science Foundation, University of Cape Town-South Africa, University of Pittsburg, Jefferson University Med Sch., Wiley and Sons Publishing, Boise State University, Penn St. University, The Educational Testing Services- Graduate Record Exam, NIH, NSF, and various cell and molecular w88 online casino betting scientific journals. At the University, I served on numerous search committees for faculty and administrators, selection committees for faculty and student research awards, and served on the National Scholarship task Force. At the end of my career I was awarded a Fulbright Senior Scholar in Molecular-Cellular w88 online casino betting to Northern Caribbean University, Jamaica; where I worked with undergraduate students to prepare them for graduate school in the US and advised faculty towards the enhancement of their graduate programs.

Recently, I was honored by an invitation to contribute an article for theEncyclopedia of Cell w88 online casino betting,2016, a product of a global collection of editors and contributors organized by the American Society of Cell Biologists. ASCB is a network of about 9,000 cell biologists in more than 62 countries. Editors from this worldwide community chose topics covering every aspect of cell w88 online casino betting and invited the experts in each field to author articles for the encyclopedia. I am extremely privileged to have been selected to contribute an article on my research findings completed during my tenure at UNR. The first listed publication is the product of that invitation. Several of the earlier publications in the list of Selected Publications describe the findings made by my research associate, students, and me that led to the discovery of ER associated degradation (ERAD).

Education

• Post Doctoral Fellowship- Protein Biochemistry and Protein Trafficking, w88 online casino betting Colorado
• Doctor of Philosophy- Molecular w88 online casino betting & Master of Science- Genetics, University of Delaware
• Undergraduate studies- UCLA

Selected publications

• Zacchi,L.F., J.J. Caramelo,A.A. w88 online casino betting, J.L. Brodsky Endoplasmic Reticulum-Associated w88 online casino betting and Protein Quality Control,In: Ralph A Bradshaw and Philip D Stahl (Editors-in-Chief), Encyclopedia of Cell w88 online casino betting, Vol [1], Waltham, MA: Academic Press, [2016], pp. 596-611.
• Scott CM, Kruse KB, Schmidt BZ, Perlmutter DH, w88 online casino betting AA, Brodsky JL.2007. ADD66, a gene involved in the endoplasmic reticulum-associated w88 online casino betting of alpha-1- antitrypsin-Z in yeast, facilitates proteasome activity and assembly.Mol Biol w88 online casino betting. Oct;18(10):3776-87.
• Kruse KB, Dear A, Kaltenbrun KB, Crum BE, George PM, Brennan SO, andw88 online casino betting AA.2006. Mutant Fibrinogen Cleared from the ER via ERAD and Autophagy: An Explanation for Liver Disease.American J Pathology, 168:1299-1308. *Recommended for ASIP CME program
• w88 online casino betting, AAand w88 online casino betting, JL.2006. Recognition and Delivery of ERAD Substrates and Alternative Paths to w88 online casino betting Survival. In Dislocation and Degradation of Proteins from the Endoplasmic Reticulum,Current Topics in Micro and Immunology,300:17-40 Springer-Verlag Berlin Heidelberg
• Kruse, KB, w88 online casino betting, JB, andw88 online casino betting, AA.2006.Autophagy: An ER w88 online casino betting Quality Control Process.Autophagy, 2:135-137
• Kruse, KB, w88 online casino betting, JB, andw88 online casino betting, AA.2006.Characterization of an ERAD Gene as VPS30/ATG6 Reveals Two Alternative and Functionally Distinct w88 online casino betting Quality Control Pathways:Molecular w88 online casino betting Cell,17:203-12 (published November 2, 2005 as 10.1091/mbc.E04-09-0779). *Recommended by Faculty of 1000
• Lee, RJ,w88 online casino betting, AA,and w88 online casino betting, JL.2005. Reconstitution of ER Associated w88 online casino betting (ERAD) using Yeast Membranes and Cytosol.Methods Molecular w88 online casino betting301:175-184
• Lee RJ, Liu CW, Harty C,w88 online casino betting AA, Latterich M, Romisch K, DeMartino GN, Thomas PJ, w88 online casino betting JL.2004. Uncoupling retro-translocation and degradation in the w88 online casino betting a soluble protein.EMBO J. 23(11):2206-15
• Palmer EA, Kruse KB, Fewell SW, Buchanan SM, w88 online casino betting JL,w88 online casino bettingAA.2003. Differential requirements of novel A1PiZ w88 online casino betting deficient (ADD) genes in ER-associated protein w88 online casino betting. J w88 online casino betting Sci. 116:2361-73
• w88 online casino betting AA, and w88 online casino betting, JL.2003. Evolving questions and paradigm shifts in endoplasmic-reticulum-associated w88 online casino betting (ERAD).BioEssays25:868-877.
• Zhang, Y., G. Nijbroek, M. L. Sullivan,A. A. w88 online casino betting, and J. L. w88 online casino betting.2002. The Hsp70 molecular chaperone facilitates the ER associated w88 online casino betting of the Cystic Fibrosis Transmembrane Conductance Regulator in yeast.Mol. Biol. w88 online casino betting12:1303-1314
• Brodsky, J.L., Werner, E.D., Dubas, M.E., Goeckeler JL, Kruse KB, w88 online casino betting AA., 1999 The requirement for molecular chaperones during endoplasmic reticulum-associated protein degradation demonstrates that protein export and import are mechanistically distinct. Journal of Biological Chemistry 274, 3453-3460.
• Werner, E.D., Brodsky, J.L., w88 online casino betting, A.A., 1996. Proteasome-dependent endoplasmic reticulum-associated protein degradation: An unconventional route to a familiar fate. Proceedings of the National Academy of Sciences of the United States of America 93, 13797-13801.
• w88 online casino betting, A.A., Karpichev, I.V., Ernaga, J.E., et al., 1996. Yeast mutants deficient in ER-associated degradation of the Z variant of alpha-1-protease inhibitor. Genetics 144, 1355-1362.
• McCracken, A.A., Brodsky, J.L., 1996. Assembly of ER-associated protein degradation in vitro: Dependence on cytosol, calnexin, and ATP. Journal of Cell w88 online casino betting 132, 291-298.
• McCracken, A.A., Kruse, K.B., 1993. Selective protein degradation in the yeast exocytic pathway. Molecular w88 online casino betting of the Cell 4, 729-736.