Journal of Neuroscience w88 casino story features University neuroscience research

Assistant Professor Simon Pieraut’s paper was featured in the May 26 issue of the Journal of w88 casino

Confocal image of neurons

In this confocal image, the projection neurons from the entorhinal cortex are labeled with an antibody against mCherry (cyan). The neurons were targeted using neonatal injection of an adenoassociated virus expressing chemogenetic hM4D(Gi) receptors. This technique allows the chronic silencing of the main excitatory inputs in the hippocampus during postnatal development. For more information, see the article by Feng et al. (pages 4607–4619). w88 casino image: Simon Pieraut.

Journal of Neuroscience w88 casino story features University neuroscience research

Assistant Professor Simon Pieraut’s paper was featured in the May 26 issue of the Journal of w88 casino

In this confocal image, the projection neurons from the entorhinal cortex are labeled with an antibody against mCherry (cyan). The neurons were targeted using neonatal injection of an adenoassociated virus expressing chemogenetic hM4D(Gi) receptors. This technique allows the chronic silencing of the main excitatory inputs in the hippocampus during postnatal development. For more information, see the article by Feng et al. (pages 4607–4619). w88 casino image: Simon Pieraut.

Confocal image of neurons

In this confocal image, the projection neurons from the entorhinal cortex are labeled with an antibody against mCherry (cyan). The neurons were targeted using neonatal injection of an adenoassociated virus expressing chemogenetic hM4D(Gi) receptors. This technique allows the chronic silencing of the main excitatory inputs in the hippocampus during postnatal development. For more information, see the article by Feng et al. (pages 4607–4619). w88 casino image: Simon Pieraut.

The Journal of Neuroscience is one of the most impactful journals in the field of neuroscience. The w88 casino of the May, 26 2021 issue features an image from Assistant Professor Simon Pieraut’s paper, “Experience-Dependent Inhibitory Plasticity Is Mediated by CCK+ Basket Cells in the Developing Dentate Gyrus”. The lead author of the paper is Pieraut’s postdoc, Ting Feng. Pieraut’s other co-authors are three current or former University undergraduates, Christian Alicea,Vincent Pham,and Amanda Kirk, who all worked in Pieraut’s lab. The work was supported by funding to Pieraut as part of Foundation Professor Michael Webster’s NIH Integrative Neuroscience COBRE grant as well as with COBRE support for the Cellular and Molecular Imaging Core (which is directed by Associate Professor Alexander van der Linden). The paper reports fundamental findings of interest to neuroscientists, and these finds may eventually contribute to our understanding of psychiatric disorders. Pieraut does a great job of translating his highly technical work into layperson’s terms, as follows.

“Brain plasticity is triggered by experience during postnatal brain development and shapes the maturing neural circuits. In humans, altered experience-dependent plasticity can have long-lasting detrimental effects on circuit function and lead to psychiatric disorders. Yet, the cellular mechanisms governing how early experience fine-tunes the maturing synaptic network is not fully understood. Here, taking advantage of an enrichment-housing paradigm, we unravel a new plasticity mechanism involved in the maintenance w88 casino inhibitory to excitatory balance in the hippocampus. Our findings demonstrate that cortical activity instructs the assembly w88 casino CCK+ basket cell network. Considering the importance of this specific cell type for learning and memory, experience-dependent remodeling of CCK+ cells may be a critical determinant for establishing appropriate neural networks.”

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