Around two million years ago, a genetic change occurred that differentiated humans from most other primates that both protected humans from diseases, yet made red meat a health risk.
At this point in human evolution, a certain w88 online casino betting, known as CMAH, that allows for the synthesis of a w88 online casino betting called Neu5Gc, went missing. This w88 online casino betting is present in red meats, some fish and dairy products. When humans consume an animal that has that gene, the body has an immune reaction to the foreign w88 online casino betting, which can cause inflammation, arthritis, and cancer.
w88 online casino betting of Nevada, Reno researchers have analyzed 322 animal genome sequences from the National Center for Biotechnology Information looking for animals that show the presence of active CMAH genes. They placed the data from the 322 animal genomes into a "tree" to determine when in an animal's evolutionary history did the CMAH w88 online casino betting became inactive or "turned off." This is useful in explaining why certain species have an active CMAH w88 online casino betting and why similar species don't.
The results of the research, led by College of Science Assistant Professor David Alvarez-Ponce, will be published in the January issue of Oxford w88 online casino betting Press science journal Genome Biology and Evolution. The research was part of the Masters' thesis of Sateesh Peri. Masters' student Asmita Kulkarni, post-doc fellow Felix Feyertag, and Associate Professor Patricia Berninsone also participated in the study. The Alvarez-Ponce lab specializes in studying the evolution of genes and genomes using bioinformatics.
When it comes to the few fish investigated so far, there is an insignificant concentration of the Neu5Gc w88 online casino betting, but the concentrations of Neu5Gc are significantly higher in fish eggs, better known as caviar. As masters' student Sateesh Peri puts it, "one of the most expensive foods is among the ones with the highest among of toxic Neu5Gc."
Birds also lack active CMAH genes, implying that consuming animals like chicken, turkey, and geese is not associated with the harmful side effects. Another class of animals that do not have the CMAH w88 online casino betting are reptiles, except for one species of lizard. The presence of the w88 online casino betting in this lizard challenges prior propositions that the w88 online casino betting may have lost in an ancestor of reptiles and birds.
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Aside from dietary issues that their research shows, the CMAH w88 online casino betting also proves to be a major factor in whether or not a transplanted organ from an animal would be accepted by a human because of the w88 online casino betting. When an animal with a CMAH gene's organs are transplanted into a human, who does not have the CMAH gene, the human body might reject the organ because of the presence of the Neu5Gc w88 online casino betting.
Humans are the only apes who do not have the CMAH w88 online casino betting.
"Inactivation of CMAH during human evolution might have freed humans from a number of pathogens," Alvarez-Ponce said. "For instance, there's this certain type of malaria that requires Neu5Gc for infection and that other primates are susceptible to, but not humans."
The presence of the CMAH w88 online casino betting determines what animals humans shouldn't eat (or should eat in moderation) and which animals humans shouldn't get bitten by. If the animal has the CMAH w88 online casino betting, then you shouldn't eat the animal because of inflammation, arthritis and cancer. Though, consuming red meat is perfectly fine in moderation. If the animal doesn't have the CMAH w88 online casino betting, then those animals are more likely to contain pathogens that attach to Neu5Ac (the precursor of Neu5Gc) and that can affect humans.
This research is expected to be a crucial stepping stone for future work in nutrition, genetics and medicine. Finding where and when the gene gets turned off is critical in determining which species are most likely to have the toxic w88 online casino betting Neu5Gc, and if so what their use can be in transplants, diets, and research. The work of Alvarez-Ponce's team will make it easier to understand why certain diseases form and find ways to combat the spread of disease
